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April 8, 2024
From Skin to Egg: IVG's Potential to Transform Fertility Treatment
Since the groundbreaking birth of the first IVF baby in 1978, over ten million children worldwide have been blessed with life through assisted reproductive technologies. IVF has paved the way for countless individuals to become parents and revolutionized fertility care.
Now, researchers at Oregon Health Science University are making headlines with their advances in in vitro gametogenesis IVG, a technique that holds the potential to redefine fertility treatment once more. While IVG remns in its early stages of development, its promise is undeniable as it offers new possibilities for women struggling with advanced maternal age or inability to produce viable eggs due to prior treatments such as cancer therapies, and for same-sex couples seeking biological connections.
How IVG Works
Senior author Dr. Shoukhrat Mitalipov, director of the OHSU Center for Embryonic Cell and Gene Therapy, explns that the mn goal of IVG is to produce eggs from patients who lack their own viable options. This cutting-edge technique transforms skin cells into egg-producing capabilities, potentially empowering women whose biological clocks have wound down or those unable to provide their own eggs due to medical reasons. It holds promise for men in same-sex relationships as well, enabling both partners to be genetically connected to the child.
The IVG Process
OHSU researchers have outlined this technique in a mouse model, marking an alternative approach compared to existing methods that focus on transforming skin cells into induced pluripotent stem cells before differentiating them into sperm or egg cells. Instead of reprogramming cells to become embryonic stem cells, OHSU's method uses a technique famously used for cloning Dolly the sheep: somatic cell nuclear transfer.
The key lies in the cytoplasm of the donated egg. When this jelly-like substance is transferred with the skin cell nucleus, it prompts the implantation process to discard half of the skin cell's chromosomes, effectively mimicking natural meiosis when cells divide to produce mature sperm or eggs. This results in an egg contning a single set of chromosomes identical to what would naturally occur.
ing egg is then fertilized through in vitro fertilization IVF, creating a diploid embryo with genetic contributions from both parentssperm and the egg derived from the skin cell. This method ensures that embryos inherit chromosomes from both biological parents, unlike Dolly who was genetically identical to her donor.
The Path Forward
IVG showcases immense potential for revolutionizing fertility treatment but is still in its early stages of development. Its safety and efficacy are yet to be fully established due to several unknowns and challenges associated with this experimental technology. As with any groundbreaking medical advancement, there may be unforeseen risks linked to IVG that require further investigation.
Our overview serves as an educational tool for the industry and should not be taken as personal medical advice or promotional material. At Medical Electronic Systems MES, we focus on providing reliable products rather than orsing specific fertility treatments.
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