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Welcome to the Preimplantation Genetic Testing PGT FAQs.
What is Preimplantation Genetic Testing PGT?
Preimplantation genetic testing, also known as preconceptional genetic screening, is a technique used in assisted reproduction processes. This test allows the identification of embryos with certn genetic disorders or chromosome abnormalities before they are implanted into the uterus.
Are there Different Types of PGT?
There are several types of PGTs:
Aneuploidy testing PGT-A: This type screens for common chromosomes numbers such as 23 or 46, ensuring no missing or extra copies.
Monogenic testing PGT-M: It is used to identify embryos with specific genetic disorders caused by single gene mutations.
Structural rearrangement testing PGT-SR: This detects translocations and other large chromosome changes that can lead to infertility issues.
Who Should Have PGT Performed?
Individuals who are at high risk due to their age, family history of specific genetic conditions, or previous miscarriages might benefit from this procedure.
How is PGT Performed?
involves:
Embryos are fertilized in vitro.
After embryonic development, embryos undergo biopsy where a small cell is removed for analysis typically day 5 blastocysts.
Samples are analyzed by molecular techniques to identify genetic abnormalities.
Can I Use PGT with Donor Sperm or Eggs?
Yes, you can use PGT regardless of whether your gametes come from yourself, an anonymous donor, or a directed donor.
Are There Risks to the Embryos during PGT?
The biopsy process carries minimal risk. However, removing cells for analysis might slightly affect embryo viability in some cases.
When Do I Decide About PGT?
Decisions regarding PGT should be made before in vitro fertilization IVF, considering factors such as your health status and personal preferences.
Do I Need PGT if No Family History of Chromosome Conditions?
While not necessary for individuals without a family history, PGT-A can still offer peace of mind by screening embryos for common chromosome abnormalities.
What Types of Abnormalities Does PGT-A Screen For?
PGT-A screens for common chromosomal imbalances like Trisomy 21 Down syndrome, Trisomy 18, and others.
Chances of Chromosome Abnormalities in Embryos:
The risk increases with maternal age due to the higher likelihood of producing eggs with chromosome errors.
What is Moscism?
Moscism occurs when an individual has more than one cell type or combination of different genetic compositions. In PGT, it may require a more complex evaluation.
Options for Mosc Results:
Embryos that test positive can be frozen and later tested agn if possible or alternatives like donor eggs or sperm might be considered.
Benefits of PGT-A:
Identifies embryos without chromosomal abnormalities to improve pregnancy success rates.
Risks of PGT-A:
Minimal, including potential risks associated with biopsy, though psychological impact should also be evaluated.
Genetic Conditions Screening Limitations:
PGT-M cannot detect all genetic conditions due to its focus on single gene mutations.
Information Required for Monogenic Testing PGT-M or Structural Rearrangement Testing PGT-SR:
Detled medical history and, when applicable, family medical records are necessary.
Accuracy of PGT Results:
While highly accurate, no test is 100 guaranteed. Prenatal diagnosis may still be considered for certn conditions.
Normal PGT Results Do Not Eliminate Risk:
Having normal PGT results does not guarantee a healthy pregnancy or child.
Other Options if PGT Isn't Suitable:
Consideration of other treatments, genetic counseling sessions, and lifestyle adjustments might provide alternatives.
Costs and Insurance Coverage:
Discuss the financial aspects with your healthcare provider as costs can vary significantly.
Turnaround Time for Results:
Typically, results are avlable within 1-2 weeks after the biopsy sample collection.
Receiving Your Results:
Results will typically be communicated to you via phone or secure eml, deping on what is most convenient.
Understanding PGT-A Results:
Normal outcomes suggest embryos tested do not have chromosomal abnormalities; further prenatal diagnosis might still be needed.
PGT-M or PGT-SR Interpretation:
Specific conditions require a genetic counselor's expertise for interpretation.
Success Guarantee with Normal Results:
While normal PGT results are positive, no guarantee of pregnancy exists without additional reproductive factors being favorable.
Genetic Counseling:
It is highly recommed to consult with a genetic counselor before and after undergoing these procedures for comprehensive understanding and guidance.
Feel free to contact our Washington University Fertility Genetic Counselor at 314-286-2411 for further personalized advice.
For more information, visit our comprehensive guide on PGT services provided by the Washington University Fertility Reproductive Medicine Center. We m to provide a range of treatments including IVF, ICSI, LGBTQIA+ family building options like gestational carrier programs and donor services.
Our affiliation with Washington University School of Medicine ensures we offer advanced healthcare services and cutting-edge research.
For inquiries or scheduling appointments, please call us at 314-286-2400 or fax at 314-286-2455.
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At Washington University Fertility Reproductive Medicine Center, we are dedicated to supporting individuals and couples through their journey towards building a family.
Thank you for considering us as your partner in this important life decision.
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Preimplantation Genetic Testing Process Chromosome Abnormality Screening Method Benefits of PGT A for Embryos Risk Assessment in Reproductive Decisions Donor Options with PGT Procedures Genetic Counselors Role in PGT Guidance