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Introduction:
In this study, we med to investigate and compare hr tin Sn concentrations between pregnant women diagnosed with gestational diabetes mellitus GDM in the first trimester of pregnancy and healthy pregnant women residing in Beijing’s Hdian District. GDM is a significant health issue during pregnancy characterized by insulin resistance or inadequate insulin secretion by pancreatic β-cells, which can influence maternal health and fetal development.
:
A prospective, nested case-control study design was employed for this investigation. The cohort consisted of 207 pregnant women who enrolled in the study between October 2017 to September 2018 at Hdian District’s Obstetrics and Gynecology Hospital. All participants were required to complete a baseline questionnre including demographic information.
Data Collection:
Sample hr was collected from each participant during their prenatal visit, with the m of assessing tin Sn concentrations as an indicator of potential environmental exposure or dietary intake levels. A control group consisted of healthy pregnant women who did not meet the criteria for GDM based on standard diagnostic testing.
Statistical Analysis:
Descriptive statistics were used to characterize tin concentration distributions within each group, including mean, median, and interquartile range. A t-test was performed to compare concentrations between GDM-positive pregnant women and their healthy counterparts. Additionally, we explored the relationship between dietary frequency patterns and tin exposure by comparing self-reported food intake data with hr Sn levels.
Results:
We observed that the average tin concentration in the hr of pregnant women with GDM was 32 higher than in those considered healthy compared to controls p0.05. The mean concentration for the GDM group was found to be 164 ngg, while the healthy group had an average concentration of 127 ngg.
Correlation Analysis:
To determine dietary habits influencing tin exposure, we correlated self-reported frequency and quantity of food intake with hr tin concentrations. Results indicated a significant positive correlation between tin exposure in hr and the consumption of seafood p=0.03 and processed foods p0.01. However, dietary patterns differed between women with GDM versus those without, suggesting potential health implications for dietary choices during pregnancy.
:
Our findings suggest that pregnant women diagnosed with gestational diabetes mellitus exhibit significantly higher tin concentrations in hr compared to healthy pregnant women. This study rses questions about environmental exposure and dietary influences on the maternal body burden of heavy metals like tin during pregnancy. Further research is necessary to understand these relationships more fully, including assessing other potential health effects associated with higher tin levels in hr.
The implications of our study are significant for both clinical practice and public health policy, emphasizing the importance of monitoring environmental exposures and nutritional factors during pregnancy, particularly for women at risk for GDM. This information can guide interventions med at reducing maternal and neonatal risks related to tin exposure through dietary modification or other measures.
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Increased Hair Tin Levels in GDM Women Gestational Diabetes Mellitus and Tin Exposure Beijing Haidian District Prenatal Study Dietary Patterns Linked to Heavy Metal Concentration Health Implications of GDM during Pregnancy Environmental Factors Affecting Maternal Health