Establishing Normal Ranges for Plasma D Dimer in Pregnant Women in Xi'an

Establishing and Validating Reference Intervals for Plasma D-Dimer in Healthy Pregnant Women in Xi'an

Introduction:

In the realm of maternal health, understanding the biological markers that could predict and monitor risks associated with pregnancy is crucial. One such marker is plasma D-dimer, a fibrinolytic degradation product that is often elevated in conditions involving coagulation disorders or thrombotic events. This study establish and validate the reference intervals for plasma D-dimer in healthy pregnant women across different stages of pregnancy within the Xi'an region. The goal is to provide clinicians with a normal reference range for dynamic monitoring of micro-thrombotic risks during pregnancy.

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The investigation involved a comprehensive approach, incorporating an online questionnre designed to identify and recruit participants. Pregnant women who underwent routine antenatal care at the Northwest Women and Children's Hospital from February 2020 to March 2022 were included in the study. Simultaneously, a group of healthy non-pregnant women serving as controls was also enrolled. These participants were screened for eligibility based on ensuring they were free from any known coagulation disorders or thrombotic conditions.

Sample Collection and Analysis:

Blood samples were collected from each participant following standard procedures, ensuring minimal stress and discomfort. Plasma D-dimer levels were measured using validated laboratory techniques, adhering to established protocols for accuracy and reliability. Statistical analysis was performed to determine the reference intervals for D-dimer levels in both pregnant and control groups, taking into account factors such as age, gestational stage, and other relevant demographic variables.

Results:

The collected data revealed distinct patterns of plasma D-dimer levels across different stages of pregnancy, highlighting the importance of considering the unique physiological changes occurring during this period. For instance, preliminary findings suggest that D-dimer levels t to increase during the later trimesters, potentially reflecting the heightened risk of thrombotic events in pregnant women.

Discussion:

s of this study contribute significantly to the field of obstetric medicine by providing evidence-based guidelines for interpreting D-dimer levels in pregnant women. Clinicians can use these reference intervals to assess the risk of micro-thrombotic complications, thereby enabling timely interventions when necessary. Moreover, the study underscores the need for ongoing research to refine these intervals further, considering the diversity in genetic, environmental, and lifestyle factors among women in the Xi'an region.

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Establishing and validating reference intervals for plasma D-dimer in healthy pregnant women in Xi'an represents a critical step towards enhancing the management of maternal health. By providing a benchmark for normal D-dimer levels, healthcare professionals can better detect potential thrombotic risks, ultimately contributing to improved outcomes for both mothers and their unborn children. Further studies are recommed to explore the implications of these findings in broader populations and to develop personalized risk assessment strategies for pregnant women.

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